CLINICAL AND ONCOLOGICAL OUTCOME OF PATIENTS TREATED FOR BREAST CARCINOMA OVER 8 YEARS: A COMPARISON BETWEEN TRIPPLE NEGATIVE( ER/PR/Her2neu) AND NON – TRIPPLE NEGATIVE CASES OPERATED AT A TERTIARY CARE CENTRE IN NORTH INDIA – A RETROSPECTIVE CASE STUDY.

Abstract

Carcinoma Breast is the most common cancer to be diagnosed amongst women in India and worldwide. Research shows that breast cancer is not a single entity but a heterogeneous disease with various subtypes. One such subtype called the Triple Negative Breast Cancer (TNBC) has certain peculiar characteristics; however the data regarding this subtype is scarce in our country.  A retrospective observational study conducted at Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi wherein data was collected from Breast Cancer patients attending the surgical OPD between May 2011 to May 2016. The patients with metastatic disease were excluded from the study. The patients were followed up for a period of 3 years i.e. till may, 2019.A total of 583 patients were registered. 61 patients had metastatic disease and hence were excluded from the study. Of the remaining 482 patients, 110 were diagnosed to have TNBC and 372 had non-TNBC disease. The TNBC patients presented at a younger age (Average age 44.02 +/- 9.348 years) with larger tumor size (Average size 5.82 +/- 1.66 cm) with involvement of axillary lymph nodes (61.8%). A positive family history of breast cancer was noted in 1.8% of patients with TNBC and more patients with TNBC had locally advanced disease at presentation (57.2%). Upfront surgery could be performed in 38.1% of TNBC patients and 61.8% patients were offered Neo-Adjuvant Chemotherapy. There was no significant difference in the 3-year survival and recurrence rates between the two groups. In conclusion we can say that in comparison to the non-TNBC patients, TNBC patients present at a younger age with larger and more advanced tumors with early involvement of Axillary Lymph nodes requiring Neo-Adjuvant Chemotherapy.

Keywords:  TNBC, Non – TNBC, estrogen receptor, progesterone receptor, Her 2/ neu, LABC ( Locally advanced breast carcinoma).