International Journal of Medical Science And Diagnosis Research

The Study of Predictive Factors in the Contribution and Progression of Coronary Artery Disease: A Hospital Based Cross Sectional Study

2022-11-22T04:32:05+00:00

Coronary Artery Disease is an insidious disease which can present clinically with sudden onset of Symptoms that necessitate hospitalization and life saving intervention. The spectrum of clinicopathological entities can range from Stable Angina, Untable Angina and Acute Coronary Syndrome. The last but not the least entity is life threatening condition with significant Morbidity and Mortality unless timely treatment is given. There are many factors which can initiate and lead to development of the disease. The Aim of this study is to identify the Risk Factors in the causation of the coronary artery disease and there by reinforce the Knowledge of Medical Fraternity about the conditions which can predict coronary artery disease, especially Acute Coronary Syndrome[Unstable Angina ,Myocardial Infarction].

Key Words: Variable, Study, Coronary Artery Disease, Prediction, Atherosclerosis.

A Study of Cyclin D1, E-cadherin, EGFR, HER- 2, Ki67, and p53 Tumor Marker Expressions in Neoplastic and Non -neoplastic Gall Bladder Lesions and their Clinico-pathological Correlation

2022-11-27T06:55:23+00:00

Background: Worldwide gall bladder cancer (GBC) is known to be the commonest malignant tumour of the biliary tract. It is the most aggressive carcinoma of the biliary tract with short median survival from the time of diagnosis. The aggressive biologic behaviour of the carcinoma and non-availability of sensitive screening tests for early detection may be responsible for the poor prognosis associated with GBC.

Material and Methods: Patients diagnosed with neoplastic and non-neoplastic gallbladder lesions in the Department of Pathology, Subharti Medical College in India were included in the study. Gall bladder biopsies findings and the clinic-pathological data were compiled and different immune-markers diagnostic and therapeutic usefulness were studied .

Results: 24 (24.0%) of the cases were in the age group of 51-60 Years. In 38 (38.0%) of the cases the site of lesion was Fundus. 55 (55.0%) of cases had associated stones. 36 (36.0%) of them had P53: strong over expression, 40 (40.0%) of the them had ki67: strong over expression, 25 (25.0%) had EGFR: strong over expression whereas negative expression for Her2/Neu was found in 61 (61.0%) of the cases. Cyclin D1: moderate over expression was found in 27 (27.0%) of them and moderate over expression of E-cadherin were found in 22 (23.2%) cases.

Conclusions: Novel prognostic biomarkers could bring about the needed breakthrough in gall bladder cancer diagnosis and treatment. We conclude that the biomarkers studied by us may help in the identification of cases who may benefit tremendously from adjuvant and targeted therapies.

Key words: Cyclin D1, E-cadherin, EGFR, HER- 2, Ki67, p53, tumour marker, neoplastic , non –neoplastic, Gall bladder lesions.

Medical Student’s Perception of Diagnostic Surgical Pathology Course: Necessities, Difficulties and Solutions

2022-11-27T06:55:14+00:00

Background: Students’ perceptions and feedback have a significant impact on academic progress. The aim of this study was to determine the perceptions of medical students regarding the surgical pathology course taken by medical students at Northern Border University.

Material and methods: In this cross-sectional study, a questionnaire was given to medical students taking this course. The questionnaire comprised several items on students’ attitudes toward surgical pathology. And a five-point Likert scale was used. Data were analysed using Statistical Package for the Social Science (SPSS) v 20 software. Results: One hundred and fifty three questionnaires received from the students were analysed.

Discussion and Conclusions: The answers to the questionnaire showed that ‘one size fits all’ approach cannot be employed for educating the students. A combination of different strategies and methods helped improve student satisfaction, particularly in regard with case presentation studies and practical’s. New strategies were adopted not just for improving academic performance but keeping in mind future clinical practice, enhancing students’ understanding and knowledge retention abilities.

Key words: medical student’s, perception , diagnostic surgical pathology course: necessities, difficulties and solutions.