International Journal of Medical Science And Diagnosis Research

Minimising Radiation Dose in Computerised Tomography in the Investigation of Renal Stone Disease: A Teaching Hospital Audit

2021-11-11T09:04:17+00:00

Background: CTKUB is a commonly performed scan as the gold standard investigation for renal stone disease. However, CT exposes a patient to ionising radiation. The radiation delivered to the patient increases in importance given the young demographic and often need for interval imaging. To minimise exposure, low dose scanning techniques are employed, and image field is reduced to only scan relevant anatomy. A common starting point for CT KUB is often the T10 vertebra however many scans are performed starting at higher levels exposing the patient to unnecessary radiation.

Methods: A list of 100 patients who underwent CTKUB for renal stone disease at a teaching hospital was created. Following exclusion of duplicates and application of exclusion criteria 51 scans were included. Each scan was individually analysed to assess vertebral level of upper limit of kidney and vertebral level at which the CTKUB scan was started. Percentage overshoot was calculated as number of axial slices cranial to the upper aspect of the kidneys.

Results: 22% of scans included in the study were started proximal to T10, these scans had a mean percentage overshoot of 19.6% exposing the patient to excess radiation. Of the CT KUB scans started at T10 or below mean percentage overshoot was improved to 8.6%. At the level of T10 all analysed scans would avoid undershooting.

Conclusions: Implementation of a CTKUB imaging protocol which starts at T10 will minimise ionising radiation exposure whilst allowing visualisation of the complete renal tract.

Keywords: CT KUB, Radiation safety, Minimise radiation

Comparison of Response to the Concurrent Low Dose Daily Cisplatin Vs Weekly Cisplatin Vs Three Weekly Cisplatin with External Beam Radiotherapy in Carcinoma Cervix Patients of Stage IIB, IIIA & IIIB: A Prospective Study from Single Institution

2021-11-11T09:04:04+00:00

Introduction: Cervical cancer continues to be a major public health problem affecting middle-aged women, particularly in less-resourced countries. External beam radiation therapy along with intra cavitary insertion has long been the treatment of choice for locally advanced (IIB-IVA) cervical cancer, but long-term successes are limited in terms of pelvic recurrence or distant metastasis. Outcome of low dose daily versus weekly versus three weekly Cisplatin concurrent with External beam radiotherapy in locally advanced cervical carcinoma was compared in this study.

Methods: A prospective cross sectional study was carried out in J K cancer institute, Kanpur. Total 60 patients of cervical cancer were randomized into 3 arms. Arm I, Arm II and Arm III received External beam radiotherapy concurrent with either daily (8mg/m²), weekly (40 mg/m²) or three weekly (100 mg/m²) Cisplatin respectively. External beam radiotherapy was given with a dose of 50 Gy / 25 # / 5 week / 2 field or 4 field. Patients were evaluated weekly during treatment and afterwards up to 1year. Results: Most of the patients were from fourth and fifth decade, low socioeconomic strata and illiterate. Majority of the cases belong to squamous cell carcinoma (96.6%) and stage III B (55%). Objective response in arm I was 80.0%, in arm II was 75.0% and in arm III was 60.0% respectively. Statistically significant difference was noted between arm III and Arm I (80%Vs60% p<0.05). Results were better in arm I as compare to arm II but not statistically significant. (80%Vs75% P>0.05)

Conclusions: This study showed that response was better in ARM I as compared to ARM III and best results was seen with Cisplatin concurrent daily with radiation.

Keywords: Cisplatin, concurrent chemotherapy, daily, weekly, three weekly, carcinoma cervix

Eccrine Angiomatous Hamartoma: A Rare Presentation in Late Adulthood

2021-11-11T09:03:56+00:00

Eccrine angiomatous hamartoma is a tumor characterized by benign malformation of eccrine and vascular elements, occurring generally at birth or during early infancy and childhood. The rarity with which it is encountered in adults and the elderly makes it a diagnostic challenge in such age brackets. We report an interesting case of eccrine angiomatous hamartoma presenting in late adulthood confirmed by histopathology.

Keywords: Cisplatin, concurrent chemotherapy, daily, weekly, three weekly, carcinoma cervix

ABO Blood Group as a Potential Risk Factor for Dental Caries: A Cross-Sectional Study

2021-11-16T18:25:54+00:00

Introduction: Dental caries is a multifactorial disease that affects people of all ages due to a complex interplay between genetic and environmental variables. The significance of genetics in an individual's vulnerability to caries has recently been explored in scientific literature. One such inherited genetic characteristic is blood group. The relationship between blood type, lifestyle, and dental caries may shed light on the above idea.

Aim: To explore into blood type as a possible risk factor for the development of dental caries.

Material And Methods: Blood samples from 39 people of the index ages (5, 12, 15, 35-44, and 60-74 years) were taken, and blood grouping was done before oral screening to determine the DMFT index. A self-administered questionnaire was used to conduct a complete diet analysis. SPSS software was used to do statistical analysis on the data.

Results: In different age groups, there was a strong link between different blood types, DMFT index, and diet.

Conclusion: The current study's results demonstrate that genetic and epigenetic variables play a significant influence in the development of dental caries. As a result, blood groups can be utilised to detect if a certain diet is associated with the development of dental caries.

Keywords: Dental caries, ABO antigens, Blood group, DMFT index, risk predictors