EVALUATION OF SALIVARY PROCALCITONIN LEVELS IN CHRONIC PERIODONTITIS PATIENTS WITH HYPOTHYROIDISM BEFORE & AFTER NON SURGICAL PERIODONTAL THERAPY - A CLINICAL STUDY.

Abstract

Periodontitis is a highly prevalent oral disease among the middle aged to elderly people. Bidirectional relationship of periodontitis with various systemic conditions has been reported with thyroid dysfunction as one among them. Procalcitonin is considered as an inflammatory marker that is raised during infectious & inflammatory conditions. It can be measured in biological fluids like serum and saliva.
Aim: The study aimed to compare the levels of Salivary Procalcitonin in Chronic Periodontitis patients with Hypothyroidism before & after non-surgical periodontal therapy.
Settings and design: This was a randomized interventional study, wherein thirty patients participated.
Materials and methods: Thirty hypothyroid patients with chronic periodontitis aged between 35-50 years were equally divided into Group A (oral hygiene instructions) and Group B (NSPT+ oral hygiene instructions) selected from an outpatient department from general hospital in Hyderabad. A written informed consent was obtained from all the patients and the study was approved by institutional ethical committee. Statistical Analysis used: Comparison within the groups was done by Paired t-test and between the groups by Independent sample t-test. P<0.05 was considered of statistical significance. Results: Intergroup assessment showed better improvement of clinical and biochemical variables in Group B when compared to Group A which was statistically significant. Conclusion: Successful periodontal therapy results in a decrease in the procalcitonin levels along with improvement in clinical parameters. Hence, chronic periodontitis patients with hypothyroidism can benefit from non surgical periodontal therapy with reduction in inflammatory burden.
Keywords: Chronic periodontitis, Hypothyroidism, Procalcitonin, Non-surgical periodontal therapy