TO STUDY AHSG GENE (RS4918) POLYMORPHISM IN METABOLIC SYNDROME

Abstract

Background: Metabolic syndrome is a major public health issue of the present century. It consists of constellation of physical conditions and metabolic abnormalities

Materials and methods: The present case control study was conducted in department of biochemistry, Maulana Azad Medical College in collaboration with department of medicine, Lok Nayak hospital, New Delhi. Total eighty (40 cases and 40 age and sex matched controls) fulfilling inclusion and exclusion criteria were included with their informed consent.

Results: The G allele of AHSG GENE Thr256Ser C>G SNP is associated with significantly increased risk of developing metabolic syndrome. (OR:5.54,95% CI: 1.03-8.17).

Conclusion: The G allele of AHSG GENE Thr256Ser C>G SNP is associated with significantly increased risk of developing metabolic syndrome

Keywords: Metabolic syndrome, AHSG GENE, High density lipoproteins