Correlation of Lead Exposure on Calcium Metabolism, Vitamin D3 in Battery Manufacturing Workers

Abstract

Background: Chronic lead exposure from the lead-acid–battery manufacturing process has been linked to a variety of health effects, including dental health, cardiovascular disease risk, Matrix–gamma– carboxy glutamic acid protein (MGP) polymorphism, oxidative stress, immunological, genotoxicity, reproductive, neuropsychological, and pteridine metabolism with neurotransmitters synthesized.

Aim of the Work: effects of lead exposure on calcium metabolism in battery workers.

Subjects and Methods: The present study will be conducted in Department of Biochemistry, Index Medical College and research center, Indore. A total of 100 lead exposed battery workers and 100 aged (20-60 yr) matched non lead exposed controls. Blood sample was withdrawn from the anticubital vein and centrifuged to obtain serum after that serum was quantitatively analyzed for lead level, calcium, phosphorous and vitamin D3.  

Result and Conclusion: In lead-exposed battery workers, correlation analysis revealed a strong negative connection between blood lead levels and serum vitamin D levels. Similarly, serum calcium levels were found to be inversely linked with blood lead levels.

Keywords: Battery workers, Lead