DIFFERENTIAL EFFECTS OF A CCB IN MES MODEL IN RATS

Abstract

Objective: To study the anticonvulsant effect of nifedipine on maximal electroshock (MES) induced seizures in rats.

Materials and Methods: For this study, Sprague dawley albino rats (150-200g, 8-9 wks old, N=18) were used. Effects of nifedipine (2mg/kg and 5 mg/kg) via intraperitoneal injection were studied in MES seizure models. Reduction in duration of tonic hind limb extension (THLE) phase was taken as positive index of anticonvulsant activity in MES model. Statistical tests were applied to compare the effect in control and experimental groups of rats.

Results: The group of rats showed statistically significant difference with the control group (p less than 0.05) with nifedipine (2mg/kg) and (p less than 0.01) with nifedipine (5mg/kg) in MES Model

Conclusion: From our present study, we thus conclude that nifedipine possess some anticonvulsant property. It decreases duration of tonic hind limb extension phase in MES Model.

Key words: Nifedipine, Anti-convulsant, Hind limb extension, Seizures