Thrombotic Thrombocytopenic Purpura (TTP)

  • Ashraf ALakkad Internal Medicine Unit, Madinat Zayed Hospital, United Arab Emirates.
  • Mohamed Gamea Neurology Unit MZH, United Arab Emirates.
  • Hesham Hussien Critical care Unit, MZH, United Arab Emirates.
  • Mahmoud Sami Critical care Unit, MZH, United Arab Emirates.
  • Salah Eldin Khalil Nephrology Unit, MZH, United Arab Emirates.
  • Adel Ahmed Nephrology Unit, MZH, United Arab Emirates.
  • Noorullah Mohammed Cardiology Unit, MZH, United Arab Emirates

Abstract

Thrombotic thrombocytopenic purpura is a medical emergency with varied clinical manifestations. TTP is a rare condition, but one that carries a high mortality. High index of suspicion with careful evaluation of thrombocytopenia and hemolytic anemia is of paramount importance. Symptoms result from microthrombi affecting microcirculation and can be varied depending on the organs involved. Laboratory parameters of microangiopathic hemolytic anemia i.e. schitocytosis and increased LDH and indirect hyperbilirubinemia support the diagnosis. Plasma exchange is the treatment of choice. Other modalities that may provide therapeutic benefit in cases of relapsing TTP or in patients with slow or partial response to plasma exchange include vincristine and rituximab. Splenectomy done in remission may decrease recurrence in patients with relapsing TTP.

Published
2021-08-10
How to Cite
ALakkad, A., Gamea, M., Hussien, H., Sami, M., Khalil, S. E., Ahmed, A., & Mohammed, N. (2021). Thrombotic Thrombocytopenic Purpura (TTP). International Journal of Medical Science And Diagnosis Research, 5(8). https://doi.org/10.32553/ijmsdr.v5i8.833
Section
Articles