A COMPARATIVE STUDY ON EFFICACY OF FIXED COMBINATION TIMOLOL/BRINZOLAMIDE VERSUS TRAVOPROST MONO-THERAPY IN DRUG-NAÏVE OPEN-ANGLE GLAUCOMA PATIENTS.

Munib ur  Rehman; Shahid Mehmood  Diyal; Bilal Humayun  Mirza; Iqra  Qureshi; Muhammad Rizwan  Ullah

doi:10.32553/ijmsdr.v4i12.732

Munib ur Rehman Assistant Professor, Khwaja M Safdar Medical College, Sialkot.
Shahid Mehmood Diyal Associate Professor, Khwaja M Safdar Medical College, Sialkot.
Bilal Humayun Mirza Senior Registrar, DHQ Hospital, Rawalpindi.
Iqra Qureshi Post graduate resident, Lahore General Hospital, Lahore.
Muhammad Rizwan Ullah Associate Professor, Postgraduate Medical Institute, Ameer Ud Din Medical College, Lahore

DOI: https://doi.org/10.32553/ijmsdr.v4i12.732

Keywords: Glaucoma, travporost and lantoprost

Abstract

Background: Glaucoma is the cause of blindness. Beta blocker and prostaglandins are used as a first line treatment of open angle glaucoma. The exact target with mono therapy for reducing intraocular pressure is achieved within 2 years, so patient prefers fixed dose combination therapy.

Objective: For reducing intraocular pressure efficacy, travoprost mono therapy and timolol/brinzolamide fixed dose combination therapy is compared.

Material and methods: For 3 months, patients are randomly received 0.5% timolol and 0.2% brinzolamide twice daily and travporost once daily 0.004%.Then compared intraocular pressure, pulse rate, blood pressure, and cup disc ratio over 12 weeks of treatment.

Results: 27.99% and 30.49% reduction in intraocular pressure is observed with mono therapy and fixed dose combination respectively. Pulse rate (9beats/min) and systolic pressure reduction by (2.35mmHg) were seen with fixed dose combination but no cup disc ratio observed.

Conclusion: It is proved that 0.5% timolol and 0.2% brinzolamide causes more reduction in intraocular pressure than the 0.004% travporost mono therapy.

Keywords: Glaucoma, travporost and lantoprost