A COMPARATIVE STUDY ON EFFICACY OF FIXED COMBINATION TIMOLOL/BRINZOLAMIDE VERSUS TRAVOPROST MONO-THERAPY IN DRUG-NAÏVE OPEN-ANGLE GLAUCOMA PATIENTS.

  • Munib ur Rehman Assistant Professor, Khwaja M Safdar Medical College, Sialkot.
  • Shahid Mehmood Diyal Associate Professor, Khwaja M Safdar Medical College, Sialkot.
  • Bilal Humayun Mirza Senior Registrar, DHQ Hospital, Rawalpindi.
  • Iqra Qureshi Post graduate resident, Lahore General Hospital, Lahore.
  • Muhammad Rizwan Ullah Associate Professor, Postgraduate Medical Institute, Ameer Ud Din Medical College, Lahore
Keywords: Glaucoma, travporost and lantoprost

Abstract

Background: Glaucoma is the cause of blindness. Beta blocker and prostaglandins are used as a first line treatment of open angle glaucoma. The exact target with mono therapy for reducing intraocular pressure is achieved within 2 years, so patient prefers fixed dose combination therapy.

Objective: For reducing intraocular pressure efficacy, travoprost mono therapy and timolol/brinzolamide fixed dose combination therapy is compared.

Material and methods: For 3 months, patients are randomly received 0.5% timolol and 0.2% brinzolamide twice daily and travporost once daily 0.004%.Then compared intraocular pressure, pulse rate, blood pressure, and cup disc ratio over 12 weeks of treatment.

Results: 27.99% and 30.49% reduction in intraocular pressure is observed with mono therapy and fixed dose combination respectively. Pulse rate (9beats/min) and systolic pressure reduction by (2.35mmHg) were seen with fixed dose combination but no cup disc ratio observed.

Conclusion: It is proved that 0.5% timolol and 0.2% brinzolamide causes more reduction in intraocular pressure than the 0.004% travporost mono therapy.

Keywords: Glaucoma, travporost and lantoprost

Published
2020-12-19
How to Cite
Rehman, M. ur, Diyal, S. M., Mirza, B. H., Qureshi, I., & Ullah, M. R. (2020). A COMPARATIVE STUDY ON EFFICACY OF FIXED COMBINATION TIMOLOL/BRINZOLAMIDE VERSUS TRAVOPROST MONO-THERAPY IN DRUG-NAÏVE OPEN-ANGLE GLAUCOMA PATIENTS. International Journal of Medical Science And Diagnosis Research, 4(12). https://doi.org/10.32553/ijmsdr.v4i12.732
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Articles