GENE EXPRESSION PATTERN ANALYSIS FOR FORENSIC DIAGNOSIS OF SUDDEN CARDIAC DEATH

  • Saikat Das Junior Doctor (MBBS Intern), Calcutta National Medical College, Kolkata
  • Ritwik Ghosh Junior Doctor (MBBS Intern), Calcutta National Medical College, Kolkata
  • Soumeek Chowdhuri Tutor, Scottish Awardee (IAFM), Department of Forensic and State Medicine, Calcutta National Medical College, Kolkata Calcutta National Medical College, Kolkata, India

Abstract

Diagnosis of Sudden cardiac death (SCD) is challenging for forensic experts. In the current scenario, genetic analysis is rapidly gaining interest in forensic science. Previous studies are not only limited to using protein markers. In this regard, analysis of mRNA is also a key feature. Analysing mRNA offers insight into the diseases and mechanisms leading to death. It can also be used for forensic diagnostic purposes. This review article takes the help of this methodology to discuss about those mRNA species that can aid in the process of sudden cardiac death (SCD) diagnosis. These are mRNA encoding Heat Shock Protein (HSP), mRNA encoding Hemoglobin A1/2 & B, mRNA encoding Pyruvate Dehydrogenase (PDK4), mRNAs encoding Connexin 43 (Cx43) & Zonula occludens-1 (ZO1), mRNA encoding TNNI3, MYL3, TGFB1, MMP9, VEGFA and mRNA expressing Brain Natriuretic Peptide (BNP).Owing to the difficulty of diagnosing SCD, molecular markers are often developed that can aid in the process. Nowadays, mRNA is showing promising usefulness to supplement the process.

Keywords: Sudden Cardiac Death, forensic, gene expression

Published
2020-09-07
How to Cite
Saikat Das, Ritwik Ghosh, & Soumeek Chowdhuri. (2020). GENE EXPRESSION PATTERN ANALYSIS FOR FORENSIC DIAGNOSIS OF SUDDEN CARDIAC DEATH. International Journal of Medical Science And Diagnosis Research, 4(9). https://doi.org/10.32553/ijmsdr.v4i9.670
Section
Articles