A COMPARATIVE STUDY OF MDA LEVEL AS A MARKER OF OXIDATIVE STRESS IN HYPERTENSIVE PATIENTS AND CONTROLS
Background: Hypertension is recognized as most common cardiovascular disorder and a leading cause of morbidity and mortality worldwide. There is abnormal lipid peroxidation which suggested that oxidative stress is important in the pathogenesis of hypertension. This study aims at understanding the role of oxidative stress in hypertension.
Aim of the Work: The objective of this study was to determine the malondialdehyde (MDA) in patients with hypertension and healthy controls.
Subjects and Methods: Whole study population included 250 hypertensive cases and 250 controls. All individuals included in the study were submitted to: Complete history and physical examinations to evaluate exclusion criteria. Serum MDA was estimated by method of Jean et al using trichloroacetic acid and thiobarbituric acid. Mean and standard deviation were calculated for serum MDA. Statistical analysis was done using SPSS no. 20 and Microsoft excel.
Result: There was statistically higher significant increase (p value <0.001) in MDA in hypertensive cases comparison to control groups.
Conclusion: The role of oxidation mediated tissue damage in generation of hypertension in human. Oxidative stress leads hypertension and other disease like atherosclerosis and cardiovascular diseases.
Keywords: Malondialdehyde (MDA), Oxidative stress, Hypertension.