EVALUATION OF BIOCHEMICAL PROFILE IN NON TRAUMATIC COMA PATIENTS: A PROSPECTIVE HOSPITAL BASED STUDY

Abstract

Background: Non traumatic coma is a serious condition which is a very common presentation in emergency department. This study aimed at studying the biochemical changes in non traumatic coma patients.  

Materials and Methods: This study was done in Department of General Medicine, Tertiary care hospital.   The study duration is one year. A total of 50 non traumatic coma patients were included in the study based on the inclusion and exclusion criteria. All the patients demographic, clinical and biochemical data was collected. The data was expressed in number, percentage, mean and standard deviation. SPSS (16.0) version software used for statistical analysis.

Results: Maximum number of patients with age between 41-60 years. Males were more compared to females. More number of patients with metabolic disorders compared to other etiology. Increased liver enzymes, lipid profile were observed.  There is a significant increase and decrease glucose, sodium levels with increased ketonebodies and uric acid levels were observed.

Conclusion: Ceribrovascular and metabolic are the most common etiology compared to others. Significant change in the biochemical parameters was observed which can indicate the severity of the condition.

Keywords: coma, hyperglycemia, lipid profile, metabolic, liver enzyme, ketone bodies