STUDY OF SERUM VITAMIN D3 LEVELS AND RISK OF BREAST CANCER
Abstract: Objective: To assess the Risk Associations of Vitamin D3 levels and Breast
Cancer and evaluate the Correlation between Vitamin D3 levels and Breast Cancer.
Materials and Methods: This was a prospective case-control study of 50 newly diagnosed cases with Breast Cancer. The serum level of 25-hydroxy vitamin D [25(OH)D was measured by ELISA at the time of diagnosis and before the start of cancer treatment. Vitamin D deficiency was defined as 25(OH) D<10 ng/mL and Insufficiency as serum 25(OH)D levels of <20 ng/ml. Patients were followed up for a median of 18 months.
Result: In our study, the mean value of serum Vitamin D3in study group was 21.86 with SD of 31.61.While the mean value in the control group was 23.62 with a SD of 21.13. There was no substantial difference in level of mean between cases and controls leading to a statistically non-significant result (p value-0.744). In the Insufficient category the mean in the study group was 15.87±1.74 while mean in the control group was 21.87±6.80, with a p value of <0.002 thus being statistically significant. This shows the insufficiency of Vitamin D3was higher in breast cancer cases as compared to controls. On further stratification of subjects into each sub-category depending on Serum Vitamin D3 , 23 cases were found in deficient category,17 cases were in the insufficient category and 10 cases were in sufficient category further stressing upon the fact that Vitamin D deficiency is a risk factor for Breast Cancer.
Conclusion: As specified in above results 40 patients out of 50 cases were having deficient and insufficient levels of Vitamin D3 in serum thus leading to the conclusion, that deficiency of Vitamin D3 promotes carcinogenesis.
keywords: 1,25(OH)2Vitamin D3,Breast Cancer, VDR(Vitamin D Receptor)