A STUDY FOR THE LEVEL OF ADENOSINE DEAMINASE CRP AND URIC ACID IN RHEUMATOID ARTHRITIS PATIENTS
Introduction: Rheumatoid arthritis (RA) is characterized by inflammation of synovial membrane and oxidative stress has been implicated as mediators of tissue damage. Adenosine deaminase plays an important role in inflammation and uric acid, an endogenous antioxidant has free radical scavenging capacity.
Aims and Objectives: To estimate the level of ADA, CRP and uric acid in Rheumatoid arthritis patients and compare with controls.
Materials and Methods: The study group included a total of 102 subjects of which 52 were RA patients and 50 were healthy controls. Serum ADA, CRP, Uric acid and Rheumatoid factor levels were analyzed. Statistical analysis was performed using SPSS and student t test.
Results: Serum ADA, CRP and Rheumatoid factor levels were found to be significantly high in RA patients when compared to controls. No significant difference was observed in Uric acid (p<0.02) level in RA patients compared with controls.
Conclusion: There was a significant difference in the levels of ADA activity between the RA patients and healthy controls, which may indicate its usefulness in diagnosing the disease.
Keywords: Rheumatoid Arthritis, Adenosine Deaminase, Uric Acid