ROLE OF CANDIDA IN CATHETER ASSOCIATED URINARY TRACT INFECTION IN ICU PATIENTS
Background: UTI in hospitalised patients due to Candida spp. is becoming increasingly common in ICU setting. There is always a dilemma as to differentiate colonisation from true infection and whether to treat candiduria or not. The choice of antifungal is also controversial due to low urinary concentration of many antifungal drugs.
Objective: This study was conducted to assess the significance of Candida spp. as the causative agent of symptomatic CAUTI in ICU patients and perform microbiological characterization of Candida and their antifungal susceptibility pattern.
Methods: A total of 472patients admitted in medical ICU, HPBICU, Neuro ICUand put on Foley’s catheter were included in the study and followed up for the development of symptomatic CAUTI.. The samples positive for Candida spp. were identified and processed as per standard guidelines, by VITEK2 COMPACT and Germ Tube Test
Results: In this study, it was found that 23.80% (5/21) of the symptomatic CAUTI was caused by Candida spp.. Among non-albicans Candida, 4 patients had Candida tropicalis and one patient had Candida albicans
All Candida isolates were sensitive to fluconazole, voriconazole, amphotericin B and itraconazole.
Conclusion: Symptomatic catheter associated urinary tract infection with Candida spp. is becoming increasingly common. Among Candida spp., non-albicans Candida is emerging as the predominant pathogen causing CAUTI.
Keywords: Candida, Candiduria, Catheter associated urinary tract infection, Nosocomial, Intensive Care Unit