ROLE OF SALIVARY ESTRIOL TO PROGESTERONE RATIO IN PREDICTION OF PRETERM LABOUR

Abstract

Objectives: To evaluate the ratio between Salivary Estriol and progesterone in preterm labour prediction.
Study design: Department of Obstetrics and Gynecology in collaboration with Department of Biochemistry, King George Medical University, Lucknow. Study was done over one year.
Material & Methods: Antenatal women were enrolled between 28 and <37 weeks of gestation with labour pains or without labour pains attending the antenatal clinic and those admitted in Queen Mary’s Hospital, Lucknow. From each patient 5 ml of saliva was collected in cryo-vials to estimate Estriol and Progesterone by Immunoenzymatic colorimetric method of the supernatant of salivary sample.
Results: In study group mean value (0.84+0.26) of Estriol to Progesterone ratio in gestation age of <32 weeks was significantly higher that mean value (0.65+0.18) of control group. Mean value of estriol to progesterone ratio in gestational age group of 32-35 weeks in study group was 0.93+0.13 also significantly higher than the mean value of control group (0.65? 0.18 ). The p value 0.027 is statistically significant.
Conclusion: Thus, salivary estriol/progesterone ratio can be used as a predictor for detecting symptomatic and asymptomatic women at risk for preterm birth.
Keywords: Preterm labour, Estriol, Progesterone, Saliva.