CHANGING PATTERN OF REPORTING ADVERSE REACTIONS DUE TO COMMON ANTIBIOTICS USED IN FIELD OF DENTISTRY: A TREND ANALYSIS FROM 2008 TO 2018

Abstract

Background: Overuse and misuse of antibiotics has been highlighted by various international bodies, a trend in indulging self medication / over prescription of drugs by the doctors has been observed among various groups across globe.
Aim: Thus this secondary data analysis was formulated with an aim to assess the change in reporting of adverse reactions of the commonly used drug in dentistry and distribution of the reporting across countries.
Design and setting: Secondary data analysis
Methods: A secondary data analysis of the FDA Adverse Event Reporting System (FAERS, formerly AERS) data base was carried out from period of 2008 to 2018.
Results: Among the commonly used drugs in dentistry amoxicillin usage was highest (54.9%) followed by metronidazole (38.5%).Amoxicillin drug usage was highest among those aged above 65 years (55.4%),and lowest among those aged below 18 years (2.1%).Reporting of serious ADE’s was seen higher among female(59.3%) than male. Type of drug used and place of residence of the participants were significantly associated (p<0.005) with serious ADE outcomes.
Conclusion: Amoxicillin drug tends to have serious ADE when compared to other antibiotics