EARLY MORTALITY AND MORBIDITY PREDICTORS IN CHILDREN WITH DOWN'S SYNDROME
Objective: To examine the, early childhood morbidity and mortality in Down syndrome (DS) among children in the Pakistan.
Study design: The number of DS births registered by the hospitals department in 2018 to 2019 was compared with total live births (reference population) and perinatal registrations.
Results: 16 per 10,000 live births was the prevalence of DS. Compared with the reference population, the 182 children with trisomy 21 had a gestational age of 38 weeks versus 39.1 weeks (P < .001), a birth weight of 3119 g versus 3525 g in males (P < .001) and 2901 g versus 3389 g in females (P < .001), and mothers with a parity of >4.17% versus 5% (P < .001) and a mean age of 33.6 years versus 31 years (P < .001) and 33% (n = 54) >36 years). The mean age of DS diagnosis was 10.2 days in nonhospital deliveries and 1.8 days in hospital deliveries (P < .001). Children with DS were less often breast-fed (P < .05), and 86% (n = 156) were hospitalized after birth. Neonatal and infant mortality were higher in DS, 1.65% versus 0.36% (P < .02) and 4% versus 0.48% (P < 0.001), respectively.
Conclusions: DS is influenced by the mother’s age. Early childhood DS mortality have declined