CLINICOPATHOLOGICAL PROFILE OF MALE BREAST CANCER: 3 YEAR STUDY.

Abstract

Background: Breast cancer in men is a rare disease and is not commonly seen in day today oncology practice. It accounts for less than 1% of all cancers in men and less than 1% of all diagnosed breast cancer. Approximately 10% of men with breast cancer have a genetic predisposition and BRCA 2 is the most associated gene mutation. Due to relative rarity of male breast cancers, prospective randomized trials are lacking and most information on breast cancer in men has been collected from retrospective studies spanning several decades and treatment recommendations have been extrapolated from results of trials in female patients.
Materials and Methods: The purpose of this retrospective study was to analyze various clinicopathological features of male breast cancer presenting to our department between January 2016 to ending December 2018.
Results: Data from 5 male breast cancer cases was analyzed. Male breast cancer accounted for 2.64% of all breast cancer cases. The mean age at diagnosis was 60.2 years. Left breast was involved in 80% cases. Invasive duct carcinoma was the predominant histopathological variant in all cases.60% cases had modified SBR Grade ll tumors whereas lymphovascular invasion was seen in 60% cases. 60% cases presented with stage ll disease, whereas20% cases each had stage lll and IV breast cancer respectively. All (100%) cases were hormone receptor positive(ER+, PR+) and Her nu 2 overexpression was seen in 20% cases.
Conclusion: Male breast cancer though a rare disease does exist. Social programs aimed at providing education and awareness about male breast cancer will lead to earlier presentation of patients to heath care professionals and hence early diagnosis.
Keywords: Male breast cancer, Clinicopathological features, Estrogen receptors, Progesterone receptors,Her nu 2 expression,Invasive ductal carcinoma.