CORRELATION BETWEEN CIGARETTE SMOKING AND MICRO ALBUMINURIA WITH ABNORMAL RENAL FUNCTION

Abstract

Introduction: Microalbuminuria is defined as moderate increase in the level of urine in albumin. It occurs when the kidney leaks small amounts of albumin into the urine, in other words, when an abnormally high permeability for albumin in the glomerulus of the kidney occurs. Normally, the kidneys filter albumin, so if albumin is found in the urine, then it is a marker of kidney disease. The term microalbuminuria is now discouraged by Kidney Disease Improving Global Outcomes and has been replaced by moderately increased albuminuria.

Material and Methods: The present study was carried out in the Dept. of Medicine in collaboration with Dept. of Biochemistry or Central Clinical Laboratory at Prakash Institute of Medical Science & Research Urun-Islampur, Maharashtra, India from 2016 to Nov 2018. Total 100 subjects of age group 35-70 years were included in this study. Out which 70 were cigarette smokers and 30 were normal healthy control.

Results: In the present study, we found significant increased levels of urinary albumin and urinary albumin creatinine ratio in cigarette smokers as compared to non-smokers.

Conclusion: On the basis of our study results we concluded that the smokers have significantly higher levels of urine albumin and urine albumin creatinine ratio when compared to controls. The quantity of smoking has a direct effect on the urine albumin and urine albumin creatinine ratio. The urine albumin and uACR is directly related to number of cigarettes smoked per day.

Keywords: Cigarette Smokers, Renal Function, Microalbuminuria, uACR