A Study of Giant Cell Lesions of Bone

Abstract

Background: Giant cell tumours are locally aggressive benign bone lesions with typical imaging features. Giant cell tumours can affect virtually any part of the body, but tend to be situated in the appendicular skeleton, with the axial skeleton being an uncommon site of occurrence.

Methods: Retrospective analysis of 50 cases of giant-cell lesions of bone diagnosed and treated at Sardar Patel Medical College and P.B.M Hospital, Bikaner (Rajasthan) were included in the study. Each case was investigated according to age, sex and clinical examination, radiological and histopathological examination.

Results: In 48 cases out of 50 cases, giant cell tumour was located in epiphysis of tubular bones and in 2 cases it was located in axial skeleton (rare site).

Conclusion: GCTs are locally aggressive primary bone neoplasms, which characteristically involve the epiphyses of long bones. GCTs affecting axial skeleton is rare, but presence of two cases amongst a study of 50 cases compels us to keep it in differential diagnosis of any expansile osteolytic lesion of skull and vertebral bones.

Keywords:  Giant Cell, Rare Location, Histopathological Examination.