PHENOTYPE-ORIENTED TREATMENT OF BRONCHIAL ASTHMA IN CHILDREN DEPENDING ON THE TERM OF ONSET OF THE DISEASE

Abstract

Objectives: To determine and analyze the efficacy of rapidly relieving therapy during exacerbations and basic anti-inflammatory treatment in the period of bronchial asthma remission in school children with alternative phenotypes of the disease by the time of its onset.

Methods: Keeping to the principles of bioethics a comprehensive retrospective examination of 50 school children suffering from bronchial asthma was performed. The patients were divided into two clinical groups depending on the term of the onset of the disease. The first (I) clinical group included 25 children with the early onset phenotype of bronchial asthma (under 3 years of age), and the second (II) group (comparison) included 25 patients with bronchial asthma of a late onset (older than 6-years of age).

Results: Inconsiderably pronounced syndrome of bronchial obstruct ion during admission regarding exacerbation of bronchial asthma was found to occur in patients with bronchial asthma phenotype of a late onset (12,1 against 11,7 points, ?>0,05). Although, since the third day severity of obstruction of the respiratory tract prevailed in the group of children with the phenotype of an early onset. In case of the early onset phenotype daily symptoms of bronchial asthma occurred four times as much, and night ones – twice as much as compared to the patients of the II clinical group.