Correlation of Muscle Enzymes with Tsh In Hypothyroidism

Abstract

Introduction: Hypothyroidism is a common endocrine disorder resulting from deficiency of thyroid hormone or, more rarely, from their impaired activity at tissue level. This study was designed to estimate the muscle markers level in hypothyroidism cases and to assess the correlation with TSH. Methodology: Methods: In this study thyroid function tests (T3, T4 &TSH), serum muscle enzymes (CK, CKMB, LDH & AST) were measured in 100 newly diagnosed hypothyroid patients attending the Medical OPD and Laboratory of the Biochemistry Department of JLN Medical College & Hospitals, Ajmer. The results of patients were compared with 50 healthy controls of either sex of similar age group. The blood samples were collected from all the attending patients and analyzed for various serum muscle markers.  Results:-A significant increased in the levels of CK-NAC, LDH and AST and non significant elevated level of CK-MB was observed in hypothyroid cases as compared to the healthy controls. A positive correlation was found between CK, CKMB, LDH & AST levels with TSH levels and negative correlation was found with T3 and T4 levels. Conclusion: The significant elevation of serum CK, LDH & AST activities indicate muscle involvement in hypothyroidism and that these enzymes can be used as parameters for screening of hypothyroid patients.

Keywords:  Hypothyroidism, CK, CKMB, LDH, AST.