Evaluation of clinical profile and response of various antibiotics in typhoid fever

Abstract

Typhoid Fever is also known as Enteric fever caused by Salmonella Enterica Serovar typhi (S. typhi) gram-negative bacteria. In this study sample of 413 patients diagnosed with typhoid fever were taken for evaluation of clinical profile and response of various antibiotics in the treatment of typhoid fever. Our results showed that in 263 normal individuals, C-reactive protein was below 5 mg/dl. In 168 typhoid positive samples the C-reactive protein was found to be higher than 6 mg/dl whereas in 245 typhoid positive samples the C-reactive protein was found to be less than 6 mg/dl. The various biochemical tests that can help identify the bacteria were used. The results showed that catalase positive, oxidase negative, Methyl red positive, nitrate reduction positive, indole negative, urease negative, glucose positive, citrate negative, Voges Proskauer negative gelatin hydrolysis negative and positive for hydrogen sulfide. The antibiotics such as ceftriaxone + salbactum, ciproflaxin and ofloxacin were sensitive to S. typhi.

Keywords: Salmonella enterica, Typhoid fever, lipopolysaccharide, enterocolitis, diarrhea, bacteremia.