CHOLESTASIS OF PREGNANCY: A PROSPECTIVE STUDY AT SMS MEDICAL COLLEGE, JAIPUR RAJASTHAN

Abstract

Background: Intrahepatic cholestasis of pregnancy (ICP) is a liver disease unique to pregnancy. It is characterised by pruritus associated with elevated serum bile acid and/or aminotransferase level with spontaneously relief of sign & symptom within 2-3 week of delivery.

Methods: Hospital based comparative analysis in pregnant women was conducted at Department of Obstetrics and Gynaecology, SMS Medical College, Jaipur

Results: The peak value of serum bilirubin (total) ranged from 0.5-2.6 in group A and 0.40-0.80 in group B. The peak value of serum bilirubin (direct) ranged from 0.2-1.4 in group A and 0.10-0.30 in group B. The peak value of serum bilirubin (indirect) ranged from 0.2-1.2 in group A and 0.20-0.60 in group B. The peak value of SGOT ranged from 106-492 in group A and 16-28 in group B. The peak value of SGPT ranged from 112-461 in group A and 18-37 in group B. The peak value of ALP ranged from 368-1102 in group A and 68-280 in group B. The highest bilirubin level noted was 2.6 mg%. The p-value was stastically significant (0.001).

Conclusion: LFT markers were significantly increased in ICP cases as compare to control group.

Key Words: Serum bilirubin, Alkaline phosphatase, Cholestasis