A COMPARATIVE STUDY ON PROFILE OF INSULIN RESISTANCE IN VARIOUS PHENOTYPE OF PCOS AT SMS MEDICAL COLLEGE, JAIPUR RAJASTHAN

Abstract

Background- Hyperinsulinemia and insulin resistance (IR) are thought to be key pathological factors for PCOS.

Methods- This prospective case-control study was undertaken to assess the insulin resistance (HOMA-IR). 216 women newly diagnosed with PCOS were classified into one of the four potential PCOS phenotypes based on history, examination and investigations.

Results- Mean HOMA-IR value was maximum in phenotype B (5.31 ± 2.13) followed by phenotype A (4.41 ± 2.21), phenotype C (3.15 ± 1.26) and minimum in phenotype D (3.08 ± 1.52) and controls (1.38 ± 0.98). Statistically significantly higher value of HOMA-IR was seen in all phenotype of PCOS with respect to controls (p-value <0.001). Phenotype A and B also showed statistically significant difference with respect to phenotype D (p<0.001) in relation to HOMA-IR.

Conclusion- Phenotype (A and B) were more insulin resistant, had higher fasting insulin and HOMA-IR values compared to women of phenotypes C and D.

Keywords: Insulin resistance, Polycystic ovary syndrome, Phenotypes.