KINETICS OF PROCALCITONIN?INTERLEUKIN-6 AND C-REACTIVE PROTEIN AFTER SURGERY FOR JAKOB III HUMERUS LATERAL CONDYLE FRACTURES IN CHILDREN
Abstract
The objective of this study was to investigate the kinetics of procalcitonin (PCT) ?interleukin-6 (IL-6) and C-reactive protein (CRP) after surgery for Jakob III humerus lateral condyle fractures in children and the relationship with postoperative wound infection. A total of 58 Chinese children who visited our hospital between May 2016 and September 2017 with Jakob III humerus lateral condyle fractures were enrolled in this study. Blood was collected before surgery and on the 1st, 3rd, and 5th day after surgery. PCT and IL-6 were quantified by an immunoluminometric assay, while CRP was measured by an automated nephelometry.
Results: No postoperative wound infections occurred in any of the participants. Plasma levels of PCT, IL-6, and CRP reached their peak on day1 after surgery and gradually declined thereafter. Moreover, CRP levels strongly correlated with IL-6 (p<0.001) at all the time points tested.
Conclusion: None of the participants suffered from postoperative incision infection. Changes in the kinetics of circulating PCT, IL-6, and CRP in children following surgery for Jakob III humerus lateral condyle fractures may indicate infectious complications and require close attention.
Keywords: Procalcitonin?Interleukin-6 and C-reactive protein, humerus lateral condyle, fracture, children
