THYROID FUNCTION TEST IN PATIENTS OF ACUTE CORONARY SYNDROME
Abstract
Objectives: The purpose of this study was to evaluate regulation of most important metabolic hormones free T3, free T4 and TSH in patients with acute coronary syndrome (ACS) having unstable angina and/or non-ST-segment elevation acute myocardial infarction (UA/NSTEMI); ST-segment elevation acute myocardial infarction (STEMI).
Methods: We conducted a analysis of 100 patient of acute coronary syndrome admitted in Intensive Cardiac Care Unit between 40-70 yr of age in tertiary level hospital with age ,sex matched control group. Blood samples were collected on 6hr, 24-36 hr, 72hr and 7 day following admission. Clinical evaluation and electrocardiograms were performed during hospitalization.
Results: serum FT3 fell in the both subgroups (STEMI and NSTEMI/UA) as comparable to the levels in control during 24-36 hr and then Serum FT3 levels increased gradually with in subsequent days. The FT3 level returns to the normal in 78% of patients by the 7th day but not to the initial values. The serum concentration of FT4 and TSH remain in normal range without significant change in both subgroups (p > 0.05 NS).
Conclusion: Thyroid hormone system is rapidly down regulated mainly FT3 in patient of acute coronary syndrome, The degree of free T3 decrease is proportional to the severity of cardiac damage and may have a possible prognostic value. Thus, freeT3 serum levels may contribute to the elaboration of an ACS severity index.
Keyword: Acute Coronary Syndrome., T3, T4, TSH, STEMI ST segment elevation myocardial infarction. NSTEMI Non ST Segment Elevation Myocardial Infarction.
